What Works Skin — Independent · Evidence-First · Ad-FreeIssue 014 · 20 April 2026 · Next: 04 Maywhatworksskin.com

Concern · Anti-aging · Photoaging

P. 31 · GUIDE

The face the sun
actually drew.

Cumulative UV damage. Tretinoin reverses, SPF prevents.

The upstream story behind most of the visible aging conversation — solar elastosis, mottled pigment, dermal collagen loss, persistent erythema. Distinct from fine lines, which is one downstream sign. Built around the only common 'aging' diagnosis with a real prevention drug: daily SPF.

— § 01

The triggers worth tracking.

Mottled hyperpigmentation on cheeks & temples

Patchy, irregular pigment that doesn't match the symmetry of melasma. Maps to lifetime UV dose, not hormone cycles.

82%
Coarse and fine wrinkling on sun-exposed sites

The forehead, perioral, and lateral periorbital lines that read as 'older than your years' — almost always UV-driven, almost never intrinsic alone.

78%
Sallow, yellowed, leathery texture

Solar elastosis on biopsy. The skin loses its pink translucency and gains a thickened, slightly yellow cast that no moisturiser fixes.

61%
Telangiectasia and persistent erythema

Dilated superficial vessels on cheeks and nose. Often mistaken for rosacea — but the trigger is cumulative UV, not vascular reactivity.

44%

— § 02

Ingredients that actually work.

Tier
Molecule
Role
Evidence
Tier A
Mineral SPF 50+ daily
Prevention
The Australian Nambour RCT remains the reference: daily SPF reduced photoaging endpoints over 4.5 years where intermittent SPF did not.
Tier A
Tretinoin 0.025–0.05%
Reversal
Forty years of histologic and clinical evidence — the molecule that established the entire photoaging-reversal category.
Tier A
Retinol 0.3–1.0%
OTC alternative
Replicated wrinkle and pigment improvement; slower onset than tretinoin but reaches a similar destination on a 12-month timeline.
Tier A
Vitamin C 10–15% (L-ascorbic acid)
Antioxidant + collagen cofactor
Cofactor for prolyl and lysyl hydroxylase; modest visible firmness and tone improvement when paired with daily SPF.
Tier A
Hydroquinone 4% (cycled)
Pigment fade
First-line for the mottled-pigment component. Cycle 3 months on, 2 off, paired with tretinoin and SPF.
Tier A
Fractional laser (clinic)
Procedural
The procedural option that meaningfully moves dermal collagen and remodels solar elastosis. Best after a year of topical groundwork.

— § 03

The protocol.

  1. Phase 01 · Week 1–4

    Prevention first

    Mineral SPF 50+ with high UVA-PF every morning, two finger-lengths. No reversal protocol works without this in place.

  2. Phase 02 · Week 4–12

    Add the retinoid

    Begin tretinoin 0.025% every third night, escalating to nightly over 8 weeks. Buffer with a ceramide moisturiser sandwich.

  3. Phase 03 · Month 4–6

    Layer pigment correction

    If mottled pigment is dominant, add hydroquinone 4% (cycled) or azelaic acid for the eight-week cycle. Continue tretinoin throughout.

  4. Phase 04 · Year 1+

    Procedural escalation

    Once topical groundwork is established, fractional laser is the most efficient lever for dermal remodelling. Without daily SPF, the result regresses.

Bottom line

Photoaging is the only common 'aging' diagnosis with a real prevention drug. People who started SPF in their 30s do not have most of this conversation in their 60s.

Cited sources

  1. № 01pmid-2909796on /sources →
  2. № 02pmid-16230554on /sources →
  3. № 03pmid-18793029on /sources →